Researchers examined the associations between coronavirus disease 2019 (COVID-19) and incident autoimmune diseases.
A research team, led by Professor Sung Ho Park in the Department of Biological Sciences at UNIST announced the results of a study on osteoblasts that damage joint bones in patients with rheumatoid arthritis.
Scientists at University of California San Diego School of Medicine have developed an artificial intelligence (AI)-based strategy for discovering high-affinity antibody drugs.
Active rheumatoid arthritis (RA) patients whose response to methotrexate (MTX) therapy was insufficient showed improvement when MTX was combined with filgotinib, an investigational JAK–1 inhibitor, according to results of a Phase 2b clinical trial. The study titled, “Filgotinib (GLPG0634/GS-6034), an oral JAK1 selective inhibitor, is effective in combination with methotrexate (MTX) in patients with active rheumatoid arthritis […]
The European Medicines Agency (EMA) has accepted a marketing authorization application from generic pharmaceuticals developer Sandoz for the review of biosimilars for AbbVie’s Humira (adalimumab) and Janssen’s Remicade (infliximab), used in the treatment of autoimmune diseases. Remicade is widely used for rheumatoid arthritis (RA) therapy. Biosimilars are biopharmaceutical drugs that have similar properties to other licensed therapies. Sandoz announced the […]
Results of a recent study showed that biological therapy regimens, such as Enbrel (etanercept), Humira (adalimumab), Remicade (infliximab), Simponi (golimumab), or Cimzia (certolizumab), are less cost-effective compared to DMARD combination in triple therapy with Azulfidine (sulfasalazine), Plaquenil (hydroxychloroquine), and Trexall (methotrexate) in the treatment of rheumatoid arthritis (RA). Importantly, this triple therapy also was found to be […]
Kevzara (sarilumab) was approved by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with moderate to severely active rheumatoid arthritis (RA) who have not responded to or are intolerant to disease-modifying antirheumatic drugs (DMARDs) such as methotrexate (MTX). The wholesale price of the new treatment is about 30 percent less […]
Group-based quality improvement sessions, based on the recommended “treat to target” (TTT) approach, can help rheumatologists improve the quality of their care for rheumatoid arthritis (RA) patients, a recent study suggests. Results of the study, “Implementation of Treat to Target in Rheumatoid Arthritis through a Learning Collaborative: Results of the TRACTION Randomized Controlled Trial,” were […]
A potential treatment for moderate-to-severe rheumatoid arthritis, sirukumab, is under consideration by the U.S. Food and Drug Administration for approval, with the application supported by results from five Phase 3 clinical trials. Johnson & Johnson (J&J) one of the companies developing sirukumab — through its subsidiary Janssen, working with GlaxoSmithKline — said in a recent business review statement that it anticipates approval […]
Rheumatoid arthritis (RA) patients taking Remicade (infliximab) can safely switch to CT-P13 (developed by Celltrion) — a much cheaper biosimilar of Remicade — according to a Norwegian study published in The Lancet. The study, “Switching from originator infliximab to biosimilar CT-P13 compared with maintained treatment with originator infliximab (NOR-SWITCH): a 52-week, randomised, double-blind, non-inferiority trial,” was funded by […]